Inhaltsverzeichnis
The authors conclude that while modafinil probably exerts its effects via more than one mechanism, modafinil’s occupancy of the DAT probably plays a role in its pharmacological effects that should be further investigated. Hou et al studied the autonomic effects of modafinil in humans. They found that modafinil affects the locus coeruleus, which mediates pupil diameter and arousal, but it does not affect other autonomic functions, which are controlled by noreadrenergic control centers (A1 – A5) located outside of the locus coeruleus. Lin et al examined fos immunoreactivity in 26 brain sites of cats after the administration of amphetamine, methylphenidate, or modafinil. They found that modafinil induced very little fos-like immunoreactivity in the cortex, but it did induce fos labeling in the anterior hypothalamus and nearby areas, in contrast to amphetamine and methylphenidate. They also noted no fos labeling in the basal forebrain, thalamus, posterior hypothalamus, or the midbrain tegmentum as a result of modafinil administration.
- Laboratory and/or medical tests may be performed periodically to monitor your progress or check for side effects.
- Lorazepamlorazepam increases and modafinil decreases sedation.
- Talk to your doctor about types of birth control that will work for you during and after your treatment with modafinil.
- Dose adjustments of these drugs and other drugs that are substrates for CYP2C19 may be necessary when used concomitantly with PROVIGIL .
- Lormetazepam increases and modafinil decreases sedation.
Amoxapineamoxapine increases and modafinil decreases sedation. Amobarbitalamobarbital increases and modafinil decreases sedation. Amitriptyline increases and modafinil decreases sedation. Alprazolamalprazolam increases and modafinil decreases sedation. Alfentanilalfentanil increases and modafinil decreases sedation. Voxelotorvoxelotor will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
What Is This Drug Used For?
Conivaptan will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Cobicistat will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Clarithromycin will increase the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Carbamazepine will decrease the level or effect of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
Sleep Quiz: Sleep Hygiene & Sleep Facts
Provigil is a prescription medicine used to treat the symptoms of excessive sleepiness caused by obstructive sleep apnea, narcolepsy and shift work sleep disorder. Provigil may be used alone or with other medications. We found only two neuroimaging studies examining the effects of modafinil (Ellis et al 1999; Spence et al 2005) both of which used BOLD fMRI to observe event-related circulatory changes in the brain. Notably, the study involving schizophrenic subjects measured event related changes in a working memory task, while the study comparing narcoleptic and normal subjects measured event-related changes during sensory stimulation. In contrast to this, the stimulant amphetamine simply increases blood flow changes in cortical activation . Thus, these studies provide further evidence that modafinil’s stimulant properties are the result of enhanced whole brain function rather than localized neural excitation.
Read it again each time this drug is refilled. If you have any questions about this drug, please talk with the doctor, pharmacist, or other health care provider. Some drugs may have another patient information leaflet. If you have any questions about this drug, please talk with your doctor, nurse, pharmacist, valacyclovir or other health care provider. Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy.